Most their for her Ernie Pook's Comeek comic strip, this cartoonist and writer also penned several graphic and illustrated novels, including Cruddy (1999), One! Hundred! Demons! (2002), and What It Is (2008). She was the 2009 recipient of the Eisner Award for Best Reality-Based Comic Work.
She earned a Fine Arts degree from The Evergreen State College in Olympia, Washington.
Her 1998 work The Good Times Are Killing Me deals with a friendship between children of different races. She adapted the book into an early 1990s Off-Broadway play.
She grew up in Wisconsin and Washington as the daughter of a Filipina-Irish mother and a Norwegian-Irish father. Following her marriage to naturalist Kevin Kawula, she settled on a Wisconsin dairy farm.
During the 1980s, she was romantically involved with National Public Radio host Ira Glass.