For her starring role in the 1996 Urdu-language film Kelona, Meera won Pakistani cinema's prestigious Nigar Award for Best Actress. Her other notable screen acting performances include Veena in the 2004 Lollywood feature Salakhain and Divya in the 2005 Bollywood film Nazar.
Before launching her screen acting career, she worked as a stage performer and a model. She appeared in her first film, Kanta, in 1995.
She was cast as Aswad's (actor Ajab Gul's) wife in the award-winning Pakistani thriller Khoey Ho Tum Kahan (2001).
Born Irtiza Rubab to Punjabi parents Shafqat Rubab and Sarwar Shah, she grew up in Sheikhupura and Lahore, Pakistan. She has five siblings. She later married Captain Naveed Pervaiz.
She and the Indian singer-turned-actor Lucky Ali both appear in the 2005 Hindi movie Kasak.